Reproduction Abstracts

Introduction: Placentation involves trophoblast cell invasion into the decidua to remodel maternal arteries. Interleukin (IL)-11 is critical for human trophoblast cell migration/invasion in vitro, however its role in placentation in vivo has not been investigated. We hypothesised that IL11 plays a critical role in trophoblast function during placentation. The aim of this study was to examine the effect of IL11 inhibition on placentation in mice.<p class="...

Introduction: During the establishment of pregnancy, extravillous trophoblast (EVT) must invade through the decidua to form a functional placenta. Impaired decidualization is associated with placental insufficiency, including preeclampsia. The mechanisms by which decidual cells interact with EVT remain largely unknown. We hypothesised that decidual–EVT interactions are critical for appropriate invasion.Methods: Primary human endometrial stromal cell...

Introduction: Ectopic pregnancy is unique to humans and a leading cause of maternal morbidity/mortality however the etiology remains unknown. Leukemia inhibitory factor (LIF) has roles in extravillous-trophoblast adhesion/invasion and is expressed in ectopic pregnancy. We hypothesised that LIF facilitates blastocyst adhesion/invasion in the fallopian tube (FT), contributing to ectopic pregnancy. LIF blockade could serve as a treatment strategy.Methods: W...